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The brain accumulation and binding of [3H]PK11195 (1-(2-chlorophenyl)-N-methyl-N-[1-methyl-1H-indol-3-yl]-1-isoquinoline carboxamide) a ligand for peripheral benzodiazepine receptor (PBR) are reduced by estrogen in rats. Because the PBRs can be recovered from the cytosol fraction of brain and are located in the myelin sheaths of oligodendrocytes, we now have investigated whether these changes in PBRs are associated with alterations in oligodendrocyte viability and myelin sheath-specific proteins. To this end, oligodendrocytes were prepared by differential centrifugation from the brain of female, androgen-intact and orchidectomized (ORX), hypophysectomized (Hypo), and estradiol (E2)-treated rats. To establish whether the reduction in PBRs induced by E2 could be specifically attributed to oligodendrocytes, we prepared two additional oligodendrocyte-depleted preparations, one by centrifuging the Hypo plus ORX rats and another by using a guinea pig anti-O1 antibody. In parallel to the PBRs, we analyzed myelin sheath-specific proteins using Western blot analysis of acetylcholinesterase (AchE), myelin basic protein (MBP), and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase). Only AchE and MBP showed a significant reduction in the E2-treated group of Hypo rats. In contrast

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We conducted a retrospective review of 65 consecutive cases of pancreatic carcinoma encountered in the last 14 years at our institution. Our patients had an average age of 69 years (range, 45-89), and a male:female ratio of 1:1.2. Whereas 30 (47%) patients were alcoholic, 13 (20%) patients had a history of smoking and no other risk factor. All patients were treated with attempted curative resection (n = 18, 27%) or palliative surgery (n = 47, 73%). Overall, 13 (20%) patients were upstaged from stage I at operation. Twenty-eight patients (43%) had no evidence of neoplasia at postoperative histologic examination. Postoperative morbidity was 41% and postoperative mortality was 5%. Over a mean follow-up period of 26 months (range, 1-280 months), disease recurred in 10 patients
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