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Winstrol binds to androgen receptors and the lowers SHBG levels, thus allowing testosterone and Tren to stimulate their anabolic effects. In a test tube system [33],[34],[35], Winstrol is a highly stable protein and does not undergo degradation [56] and can be used safely in pregnancy because of its bioavailability: the body rapidly absorbs it [55] and it is excreted largely unchanged in the urine. Therefore, Winstrol can be used to deliver hormone replacement therapy (HRT) at reasonable cost to pregnant women. In an animal model, Winstrol is a potent androgen receptor antagonist; thus, it effectively counteracts the effects of circulating androgens and may offer women an alternative to HRT that can lower the risk of pregnancy and reduce the need for medical supervision and administration. This effect was recently confirmed by the use of a synthetic anabolic steroid HGH, the only naturally obtained anabolic steroid currently accepted to treat hypogonadism [48] [57]. However, the possibility that Winstrol’s anabolic effect may be beneficial to humans remains a controversial concept. This is not surprising because no published study on the effects of Winstrol has been done. Furthermore, Winstrol’s side effect profile varies by species and dose. Hormonal effects have not been studied for Winstrol in cats or dogs. Winstrol is not as effective in humans as for humans, and there has been a decrease in its usage in the United States since 2007 [48]. Although Winstrol does not stimulate muscle growth, it does increase body mass and bone mass in animals [48,58]] [59], which may explain why humans may find it more attractive. Winstrol does not act on the central nervous system in rats [57] and rats can respond to this drug by decreasing their testosterone levels. If Winstrol can have some positive effects in animals, it could serve as a potent anabolic factor for humans as well. Winstrol’s action may also be beneficial to pregnant women. As it is not as active as testosterone, it may have less adverse side effects, so it is possible that it may be a useful treatment in pregnant women [55].
4.2.3 Summary Winstrol contains very little testosterone-like or aromatase-inducing activity, but has a modest antiandrogen effect. It can also possess antiandrogen properties in animals. It should be taken with caution during pregnancy, particularly for women with orrogen-responsive hyperandrogenemia. It should have been shown that it has low blood levels of T and SHBG during early pregnancy and that it
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